|
KMID : 0881720180330050389
|
|
Journal of Food Hygiene and Safety
2018 Volume.33 No. 5 p.389 ~ p.398
|
|
|
Anti-obesity Activities of Cirsium setidens Nakai Ethanolic Extract
|
|
Cho Bong-Yeon
Choi Sun-Il
Choi Seung-Hyun
Sim Wan-Sup
Han Xionggao
Ra Moon-Jin
Kim Sun-Young
Kang Il-Jun
Han Kyoung-Chan
Lee Ok-Hwan
|
|
|
Abstract
|
|
|
|
The purpose of this study was to evaluate anti-obesity activity of Cirsium setidens Nakai test material (CNTM) in 3T3-L1 adipocytes and obese C57BL/6J mice fed with a high-fat diete using various obesity-related in vitro experiments. During adipocyte differentiation, CNTM significantly inhibited lipid accumulation and ROS production compared to controls. To evaluate whether CNTM could exert glycerol release effects on mature 3T3-L1 adipocytes, we treated cells with various concentrations of CNTM for 1 h. Treatment of mature adipocytes with 160?320 μg/mL of CNTM increased the release of glycerol, but not in a significant dose-dependent manner. Anti-adipogenic and anti-lipogenic effects of CNTM seemed to be mediated by the inhibition of PPARγ and C/EBPα. Moreover, CNTM stimulated fatty acid oxidation in an AMPK-dependent manner. CNTM-treated groups of C57BL/6J mice showed reduced body weights and adipose tissue weight with improved serum lipid profiles and adiponectin protein expression in obese C57BL/6J mice fed with a high-fat diet. These results suggest that CNTM might have anti-obesity effect on adipogenesis and lipid metabolism in vitro and in vivo. This presents the possibility of developing a treatment for obesity using nontoxic natural resources.
|
|
|
KEYWORD
|
|
|
Antiobesity, C, setidens Nakai ethanolic extract, 3T3-L1, C57BL/6J mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|